在exon 14的上游插入了loxP位点,下游则插入了带有floxed neo cassette的片段,通过Cre介导的重组,去除了exon 14。蛋白表达缺失通过 hippocampus 的 Western blot 分析得到了确认(来源:J:155003)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count