在β-geo报告基因的上游,插入了一个包含FRT、F3、loxP和Lox5171序列的条件准备型基因陷阱 cassette,接着是反向排列的loxP、Lox5171、FRT和F3位点,最后在exon 1内。这个插入保持了原基因捕获的构型,导致转录在β-geo报告基因处停止,产生一个无功能的null等位基因,可通过Flp或Cre介导的去失来恢复功能。来源:(J:236978)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129P2/OlaHsd
Gene trapped
基因捕获载体的插入
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1
6
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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