Tg(IVL-MYC*)3Gev

The human involucrin promoter drives expression of a human MYC-derived basic helix-loop-helix zipper (bHLHZip) domain in which replacement of four charged amino acids (Glu57Thr, Glu64Ile, Arg70Glu, Arg71Asn) permits it to form homodimers, as well as heterodimers with endogenous MYC that interfere with the formation of MYC/MAX dimers and suppress binding to E-box elements. Immunohistochemical analysis of transgenic mouse skin using an antibody to the mutant bHLHZip demonstrated expression of the mutant protein in most suprabasal interfollicular keratinocytes and in the inner root sheath of hair follicles. (J:55801, J:101692, J:153799)