编码金属蛋白酶切割位点的基因部分发生了突变,从SSFEKQI变成了SEEAAAI,这阻碍了可溶性肽的产生。不过,膜结合的版本仍然能够生成。用于选择性标记的floxed neo cassette通过小鼠的生殖细胞通过Cre介导的重组已被剔除。(来源:J:153501)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
B6.Cg-Thy1a
Targeted
核苷酸替换
--
1
3
3

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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