在第六个内含子插入了loxP引导的诺姆西林插件,并在第三个loxP位点位于第三内含子。通过Cre介导的重组,去除了4到6号外显子。这种缺失导致了框架错乱的突变。蛋白表达缺失通过在脾、胸腺、肾、肝和脑的提取物中进行 Western Blot 来确认。(来源:J:153216)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S6/SvEvTac
Targeted
插入,基因内删除
--
1
--
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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