在exon 20上游插入了loxP位点,通过同源重组,又插入了frt标签的neo cassette和第二个loxP位点在exon 21下游。随后,Flp和Cre介导的重组移除了neo cassette以及exons 20和21。(来源:J:153222)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count