Ctsa^tm1.1Avps

Exon 6 was replaced with one that contains nucleotide substitutions (c.571AGC>GCA) resulting in an amino acid substitution of alanine for serine at position 190 (S190A). A floxed neo cassette was inserted downstream of exon 7 and was removed by germ line cre mdiated recombination. While the protein is expressed almost no enzymatic activity is detected. (J:153297)