L1L2_Bact_P cassette被插入了染色体8的106,104,661位,位于关键外显子(Build GRCm39)上游。该 cassette 包含FRT位点、lacZ序列和一个loxP位点。FRT位点后面跟着由人类β-actin启动子驱动的诺卡因抗性基因、SV40polyA,然后是一个第二个FRT位点和第二个loxP位点。插入该cassette会创建一个报告基因敲除小鼠。Cre表达会移除诺卡因选择性 cassette。更多关于这种IKMC等位基因靶向策略的信息,请参阅http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml(J:148605, J:173534)。

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6N
Targeted
插入
--
1
1
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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