L1L2_Pgk_P cassette被插入到染色体9的123,540,649位点,位于关键外显子(基于GRCm39构建)。该 cassette 包含FRT位点、lacZ序列和一个loxP位点。第一个loxP位点后面跟着由PGK启动子驱动的诺卡因抗性基因、SV40polyA,第二个FRT位点,以及第二个loxP位点。插入该 cassette 会生成一个报告基因敲除小鼠。Cre表达会去除诺卡因选择性 cassette。欲了解针对此和其他IKMC等位基因的靶向策略详情,请参阅http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml(文献J:148605, J:173534, J:226512)。

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6N-Atm1Brd
Targeted
插入
--
1
2
6

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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