使用细菌人工染色体(BAC)文库,获得了一个包含完整小鼠Trp53(转录因子53,也称为转化相关蛋白53)基因的130kb BAC,它在"自然基因组背景"中。Trp53基因位于该染色体的末端,而BAC的另一端位于Dnahc2基因的中间。这条线携带着这个转录因子的单拷贝基因。 (Source: BAC library was used to isolate a 130kb BAC containing the entire mouse Trp53 gene in its native genomic context, with one copy integrated in the Dnahc2 gene region.)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count