内源基因的启动子驱动表达一段编码融合蛋白的DNA序列,其中Cre重组酶与去掉了末端42个氨基酸的人类孕激素受体的LBD相连。这种融合的重组蛋白不是永久活跃的,其活性需通过米非司酮(mifepristone)的结合,这是一种人造孕激素RU486,与截短的孕激素LBD结合后诱导激活。(来源:J:104881, J:122587)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Not Specified
Targeted
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1
2
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

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PMID
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Year
IF
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