在exon 1上游插入了loxP位点,而在exon 20下游则插入了带有3' loxP标记的frt flanked neo cassette。通过小鼠的生殖细胞中flp介导的重组,neo cassette被移除,使得3到20号外显子被标记为可剪接。(来源:J:152729)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count