设计了一个靶向载体,包含一个Frt-介导的诺卡因抗性(neo)基因座,接着是LoxP位点,位于exon 2上游,然后是另一个LoxP位点在exon 6下游。随后通过Cre介导的重组,去除了exon 2。 Western blot结果显示,纯合小鼠子宫组织中没有检测到蛋白质表达。(来源:J:152701)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129
Targeted
插入,基因内删除
--
1
5
4

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

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PMID
Journal
Year
IF
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