在人类DSCR1(RCAN1)短变异体的启动子区域(-1,664/+83)驱动了lacZ报告基因在Hprt定位区内的表达。Hprt定位区的启动子和起始区域被包含在构建的3'末端,以修正ES细胞内的内源性缺陷。该报告基因在杂合胚胎的内皮细胞中均匀表达,但在出生后会下调。在成年大脑、心脏、肺和肾脏的少数内皮细胞中检测到了报告基因的表达。(来源:J:152536)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Not Specified
Targeted
插入
--
1
2
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
Show/Hide columns
Phenotypes

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
微信
信息比对
科研助手
使用教程
回到顶部