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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
基因编辑小鼠
Sirt1
tm3Fwa
Alias:
Sirt1
loxP
SIRT1
F
Sirt1-E4
fl
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基础信息
表型特征
文献报道
在内皮3号插入了反向排列的诺卡因抗性基因座。接着在exon 4下游位置插入了一个loxP序列。生成的ES细胞中,exon 4被loxP位点包裹。这些突变的ES细胞被用于培育Sirt1tm1Fwa小鼠。(来源:J:85542)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
4359275
129S6/SvEvTac
Targeted
插入
--
1
--
59
Phenotypes
Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes
References Literature
Title
PMID
Journal
Year
IF
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