人类6kb的角蛋白5(KRT5)启动子驱动cre/ERT2 cassette。cre/ERT2由pCI哺乳动物表达载体的内含子和polyadenylation序列环绕。构建物被注入受精卵中,获得了11个杂交瘤系,其中1个在气管基底细胞中表现出强效重组,现在在C57BL/6 x C3H背景上繁育和维持。(来源:J:152012)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count