Deletion of exons 1 to 12 occurred by replacement with an autodeleting cre+neo cassette (loxP site, the mouse Ace (angiotensin I converting enzyme (peptidyl-dipeptidase A) 1) promoter, the cre recombinase gene, a neomycin resistance gene cassette, and a second loxP site). The whole coding region was removed. (J:152363)