Tg(Vav1-NUP98/HOXD13)C1Apla

A transgenic construct containing cDNA of the amino-terminal region of the human nucleoporin 98kDa (NUP98) fused to the homeodomain of the human homeobox D13 (HOXD13) under the control of the 3' and 5' mouse vav 1 oncogene (Vav1) regulatory elements and SV40 polyadenylation site sequence was injected into fertilized FVB/N mouse eggs. Five founders were obtained but only 1 line, C1, transmitted the transgene. Founder line C1 was subsequently established. Expression is detected in hematopoietic tissues, such as thymus, spleen, and bone marrow, but not is nonhematopoietic tissues like brain, kidney, and liver. (J:107446)