Tg(Vav1-NUP98/HOXD13)G2Apla

A transgenic construct containing cDNA of the amino-terminal region of the human nucleoporin 98kDa (NUP98) fused to the homeodomain of the human homeobox D13 (HOXD13) under the control of the 3' and 5' mouse vav 1 oncogene (Vav1) regulatory elements and SV40 polyadenylation site sequence was injected into fertilized C57BL/6 mouse eggs. Founder line G2 was subsequently established. The transgene is expressed specifically in hematopoietic tissues and is detected in thymus, spleen, and bone marrow and not in brain, liver, and kidney (by Northern blot analysis of total RNA). (J:107446)