Snord116^tm1Jbro

A cassette containing the 5' half of the HPRT mini-gene (driven by the Pgk promoter), a loxP site and a neomycin resistance gene (driven by the Polr2a promoter), was inserted 5' of Snord116. Mice with this allele don't display a discernible phenotype. When expressed from the maternal allele, this construct forces the expression of the snoRNA genes in the, normally maternally imprinted, Snord116 and Snord115 clusters. (J:152022)