唯一编码外显子被替换成lacZ载体和一个可删除的诺卡因抗性基因。始祖小鼠与Cre转基因小鼠杂交,以剔除生殖细胞中的诺卡因选择性载体。通过脑组织提取物的RT-PCR分析,确认了内源基因失活和报告基因的表达(来源:152015)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129P2/OlaHsd
Targeted
插入,基因内删除
--
1
--
7

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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