第六和第七外显子被替换成一个带有floxed neo标签、floxed STOP以及人类RUNX1编码区域的元件。当通过Cre介导的重组去除floxed neo和STOP cassette时,产生了Etv6和人类RUNX1(或TEL-AML1)的融合产物。(来源:J:151639)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S1/Sv-Oca2+ Tyr+ Kitl+
Targeted
插入,基因内删除
--
1
12
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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