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中文
使用了针对exon 22的靶向载体，替换第750位的苯丙氨酸为天冬氨酸，这是一个预测会阻碍LXCXE结合凹槽空间的大型氨基酸。Southern blot结果显示了重组的成功。对突变纤维细胞的分析证实了蛋白质水平与野生型细胞相当。与在生殖细胞中表达Cre重组酶的 mice杂交移除了载体中包含的 floxed neo序列。(来源：J:151417)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
