在exon 1中引入了突变,导致第33位的密码子从精氨酸(R33)变为谷氨酰胺(Q33)。随后在exon 1之后插入了loxP位点和frt标记的PGK-neomycin筛选元件。为了去除选择性片段,雄性小鼠与表达flp重组酶的雌性小鼠杂交。(来源:J:151367)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129X1/SvJ
Targeted
单点
--
1
4
8

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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