将包含一个splice接受器-beta geo插件和polyadenylation序列的基因陷阱载体pGTxf插入到了第七外显子和第八外显子之间。这种插入导致了基因转录和表达的中断。 Western blot分析证实了纯合突变小鼠肝脏、脂肪和骨骼肌组织匀浆中没有蛋白质表达。(来源:J:211794)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129P2/OlaHsd
Gene trapped
基因捕获载体的插入
--
1
2
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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