Vrk1^{Gt(RRR178)Byg}

Insertion of a beta-gal and neo cassette within 6174 bases 3' of the beginning of intron 3 of Vrk1. The predicted product only contains the N-terminal 72 amino acids fused with beta-gal and is catalytically inert. However, RT-PCR demonstrated only a 4.5- to 6.4-fold decrease in full length message in various adult tissues, confirmed by immunoblots, indicating this is a hypomorphic allele. (J:156653)