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A gene-trap cassette containing a splice acceptor and a poly(A) signal was inserted between exons 2 and 3, so that a spliced transcript containing exons 1 and 2 (98 out of 1262 aa) is expressed instead of the full-length transcript. RT-PCR of MEFs showed reduced mRNA expression. Western blotting of spleen, liver, heart and kidney from homozygous mice failed to detect any wild-type protein. (J:157195)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
