靶向载体被设计用来替换编码预测催化区域的9-14号外显子和部分15号外显子,这些外显子通过一个含荧光尼古丁的载体。首批杂合子小鼠与Cre转基因小鼠杂交,以去除尼古丁载体。免疫组化结果显示,纯合子嗅觉上皮中未检测到蛋白质产品。(来源:J:150514)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S6/SvEvTac
Targeted
插入,基因内删除
--
1
--
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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