Foxp2^tm2.1Woen

Exon 7 was replaced with a frt flanked neo cassette with a 5' loxP site and a modified exon 7 followed by a 3' loxP site. The modified exon 7 contains nucleotide substitutions that result in two amino acid substitutions, namely, asparagine for threonine at position 302 (T302N), and serine for asparagine at position 324 (N324S). These amino acid substitutions mimic the amino acids found in humans. Germ line, flp mediated recombination removed the neo cassette leaving exon 7 floxed. (J:150425)