在IgH基因座中,DQ52和JH1之间插入了反向排列的荧光素抗氨苄青霉素抗性基因、一个剪接接受体、一个内源性核糖体进入位点、SV40的大和小T抗原编码区域,以及额外的Emu IgH内含子增强子。通过将克隆小鼠与表达Cre的转基因小鼠杂交,目标后裔中氨苄青霉素基因被剔除。通过RT-PCR检测,B细胞中检测到了SV40 T抗原的转录片段。(来源:J:150315)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
129P2/OlaHsd
Targeted
插入
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5

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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