通过将携带敲除Gm73tm1Jxm基因为靶点的转基因小鼠与Cre转基因小鼠杂交,研究人员通过删除单个编码外显子创建了一个无功能等位基因。通过Southern blotting分析同源纯合组织提取物,确实证实了外显子的去除。(来源:J:149909)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(129X1/SvJ x 129S1/Sv)F1-Kitl+
Targeted
基因内删除
--
1
--
4

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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