在PC3 ES细胞中,通过同源重组将一个IREScreERT2 cassette紧接在Lmx1b基因的3'UTR区域后,接着插入了一个由loxP标记的PGK-neo cassette。随后,来自雄性嵌合体小鼠的Cre介导的重组会删除PGK-neo cassette。通过与C57BL/6小鼠杂交,从敲入等位基因中分离出了由PC3细胞提供的protamine-cre转基因。(来源:J:149241)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S4/SvJae-Tg(Prm-cre)70Og
Targeted
插入
--
1
5
3

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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