在exon 10上游插入了一个带有3' loxP位点的frt flanked neo cassette,接着在exon 11下游也插入了一个loxP位点。通过小鼠的生殖细胞中flp介导的重组,neo cassette被移除,使得exons 10和11被标记为可靶向操作的区域。(来源:J:149477)
Basic Information
(129X1/SvJ x 129S1/Sv)F1-Kitl+
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count