PC3 ES细胞含有一个由protamine-cre基因驱动的转录因子,标记为Tg(Prm-cre)70Og,它在雄性生殖细胞特异的protamine启动子调控下表达Cre重组酶。在雄性杂种后代中,通过Cre介导的剪切,去除了exon 6。蛋白表达缺失通过在肝脏提取物中进行 Western blot 实验得到了确认。(来源:J:148992)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S4/SvJae-Tg(Prm-cre)70Og
Targeted
插入,基因内删除
--
1
1
6

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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