通过Cre介导的重组,删除了含ATG的第二个外显子和neo cassette,这个突变的Elavl1tm1Dkon等位基因得到了验证,通过E11.5时期提取物的免疫印迹分析,没有检测到蛋白表达,这表明基因功能已被抑制。(来源:J:149149)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129P2/OlaHsd
Targeted
基因内删除
--
1
--
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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