在exon 1前1.1kb的位置插入了loxP位点,并在exon 1下游1kb处放置了一个含诺卡因抗性基因的克隆载体。通过转染含Cre表达腺病毒给具有靶向位点的ES细胞,产生了exon 1带有loxP标记的细胞系。对脾、胸腺、脑和肺组织的免疫印迹分析显示,这个位点的表达没有受到影响。(来源:J:148791)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
B6.Cg-Thy1a
Targeted
插入,基因内删除
--
1
1
10

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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