从 intron 1 的 3' 端延伸到 exon 3 的 5' 端的基因序列被替换为 intron 1 到 exon 3 缺失部分,后面跟着 puromycin 抗性基因座、loxP 突变位点、3'Hprt 微基因和 intron 1 的 3' 端到 exon 3 的 5' 端的重复。转录表达缺失通过脑组织的Northern blot分析得到了确认。(来源:J:148467)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S7/SvEvBrd-Hprt1b-m2
Targeted
Duplication, Insertion
--
1
2
3

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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