将小鼠Hdac2蛋白的编码序列插入基因座的起始exon1中,形成一个融合蛋白,包含内源性序列的前31个氨基酸。通过免疫荧光在海马CA1区域确认了Hdac2的2-3周表达。Hdac2活性通过在该区域观察到的乙酰化水平降低得到了验证(来源:J:148391)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(C57BL/6 x 129S4/SvJae)F1
Targeted
插入,基因内删除
--
1
14
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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