将小鼠Hdac2蛋白的编码序列插入基因座的起始exon1中,形成一个融合蛋白,包含内源性序列的前31个氨基酸。通过免疫荧光在海马CA1区域确认了Hdac2的2-3周表达。Hdac2活性通过在该区域观察到的乙酰化水平降低得到了验证(来源:J:148391)
Basic Information
(C57BL/6 x 129S4/SvJae)F1
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count