将Cdh5启动子区域的2.5kb片段,后面跟着cre重组酶的cDNA和SV40的polyadenylation信号,插入到了pBluescriptSKII质粒中。这个转基因片段被提取后,注入到了C57BL/6J的受精卵中。获得了三个杂交系,所有这三个在与EGFP或LacZ报告基因小鼠杂交时,都没有观察到报告基因表达的差异。特别关注了线1,据估计它含有2个Cdh5-cre基因。(来源:J:121366)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
C57BL/6J
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7

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

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PMID
Journal
Year
IF
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