这种突变移除了导致C57BL/6小鼠非阿格里农表型的11.8kb的反向转座子插入,以及607bp的周围内源性DNA,保留了一个从剪切的弗里特(FRT)标记盒中提取的单个弗里特(Frt)位点。它恢复了背侧和腹侧皮毛中阿格里农蛋白的表达。(来源:J:149352)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6N
Targeted
插入,基因内删除
显性
1
1
5

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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