Ccn2^tm1Mga

The gene was disrupted by replacement of exons 3, 4 and a part of exon 5 coding for von Willebrand factor type C domain with a transmembrane domain-lacZ/neo cassette via homologous recombination. The neo selection minigene was flanked with LoxP sites. Resulting allele produces a Ctgf N terminus/beta-gal fusion protein. (J:145696, J:200671)