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在exon 4的上游插入了loxP位点，通过同源重组技术，又插入了frt标记的neo cassette和另一个loxP位点在exon 4下游。随后，通过Cre介导的重组，exon 4被移除了。免疫印迹分析证实了纯合小鼠皮肤中无蛋白表达。(来源：J:147182)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
