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A loxP site was inserted into intron 13, and an FRT site flanked neomycin resistance gene cassette and a second loxP site were inserted into intron 17. Exon 17 contains nucleotide substitutions that result in the amino acid substitution of isoleucine with threonine at position 756 (p.I756T) which corresponds to the same human mutation found in patients with an X-linked retinal disorder. (J:146683)