这个基因陷阱载体包含了β-geo序列,它被插入在第5外显子下游。融合产物缺失形成活性异二聚体所需的末端46个氨基酸。通过 Western blot 在鼠胚胎成纤维细胞及多种组织中,确实验证了内源性蛋白表达缺失,但lacZ融合转录本的表达。(来源:J:146618)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129P2/OlaHsd
Gene trapped
基因捕获载体的插入
--
1
--
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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