germ line(生殖线)、通过Cre介导的重组被用来去除neo cassette和exon 3。这个exon的缺失导致了框架突变和CR1区域的过早终止。蛋白表达缺失通过E11.5胚胎提取物的 Western blot 分析得到了确认(来源:J:146415)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S4/SvJae
Targeted
插入,基因内删除
--
1
1
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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