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中文
一个反向排列的FRT引导的诺姆菌素插件替换了位于IgG1恒定区上游，包含DNA修饰位点和一个剪接捐赠体的1.7kb的5'sgamma1开关区。在将这种靶向129P2/OlaHsd ES细胞后，通过短暂表达Flpe重组酶移除了诺姆菌素插件。在(C57BL/6 x 129P2/OlaHsd)F1小鼠中，通过IgG1"a"129等位基因的缺失，证实了IgG1开关区的功能丧失。(来源：J:146428)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
