在loxP位点附近插入了含氨苄西林抗性基因和一个带有终止子的片段,同时加入了在第12位氨基酸由甘氨酸替换为天冬氨酸的常激活型Kras(G12D)。为了激活这个Kras,需要通过Cre元件去除终止子。(来源:J:146290)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S1/Sv-Oca2+ Tyr+ Kitl+
Targeted
插入
--
1
--
3

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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