在第3外显子上游插入了带有荧光素GFP和抗羟胺霉素抗性基因座的片段,同时在第4外显子下游放置了一个loxP位点。通过与Tg(rtetR-TetO-cre)40Mhz小鼠杂交,移除了选择性基因座,使得第3和4外显子被loxP位点环绕。纯合子中蛋白表达没有受到影响。(来源:J:146210)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129
Targeted
插入
--
1
4
6

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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