这个转基因包含了完整的编码小鼠ADAM3(一种金属肽酶和整合素样域3,cyritestin)的cDNA,后面跟着牛的 globin polyadenylation 启动子,并在小鼠calmegin基因的特异性睾丸启动子驱动下表达。 Western blot 实验显示,Adam3tm1Ihig纯合子小鼠的睾丸和精子中都检测到了ADAM3。(引用:J:147330)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
129S1/Sv and 129X1/SvJ and CD-1
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1
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Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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