从1到6号外显子被替换成一个带有floxed neo cassette的元件。通过在小鼠胚胎成纤维细胞中用IFN-beta处理后,蛋白表达缺失得到了 Western blot 分析的确认(来源:J:146113)
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Exons 1 through 6 were replaced with a floxed neo cassette. The absence of protein expression following treatment with IFN-beta was confirmed by western blot analysis on mouse embryo fibroblasts. (J:146113)